GPX4 Promotes Optic Nerve Regeneration and RGC Neuroprotection
Ming Yang, Fuyun Bian, Xue Feng…·Yang Hu
This study shows that GPX4 overexpression in RGCs promotes optic nerve regeneration and neuroprotection in glaucoma models.
Author
Atrium Health Wake Forest BaptistORCID 0000-0001-8630-7430Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
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Ming Yang, Fuyun Bian, Xue Feng…·Yang Hu
This study shows that GPX4 overexpression in RGCs promotes optic nerve regeneration and neuroprotection in glaucoma models.
Lindsey V. Soles, Liang Liu, Xudong Zou…·Yongsheng Shi
The paper identifies a nuclear RNA degradation code (NRDC) that recognizes transcripts with both a 5' splice site and a poly(A) junction, leading to their degradation and contributing to disease.
Liang Liu, Peiqing Sun, Wei Zhang
This study identifies intronic polyadenylation sites across 32 cancer types and links their expression to cancer characteristics and prognosis.
Liang Liu, Tamjeed Ahmed, William Jeffrey Petty…·Wei Zhang
This study analyzes SMARCA4 mutations in KRAS-mutant lung adenocarcinoma across multiple cohorts, finding adverse clinical outcomes associated with SMARCA4 mutations in both non-immunotherapy and immunotherapy-treated patients.
Ye Feng, Min Qiu, Liang Liu…·Fan Mo
This paper designs multi-epitope peptide vaccines against SARS-CoV-2 using immunoinformatics, showing they elicit strong humoral and cellular immune responses in mice.
Jie Zhang, Liang Li, Haoliang Huang…·Yang Hu
This paper develops a reversible mouse model of secondary glaucoma using silicone oil and validates it for testing neuroprotective therapies.