Transcriptomic Landscape and Immune Microenvironment AroundWound Bed Define Regenerative versus Non-regenerative Outcomesin Mouse Digit Amputation
Archana Prabahar, Connie S. Chamberlain, Ray Vanderby, William L. Murphy, William D’Angelo, Kulkarni Mangesh, Bryan N. Brown, Barsanjit Mazumder, Stephen F. Badylak, Peng Jiang
The paper investigates regenerative versus non-regenerative outcomes after mouse digit amputation by analyzing the wound bed's transcriptomic landscape and immune microenvironment, identifying key transcription factors and developing a predictive AI model.
bioRxiv · Dec 4, 2024 · PreprintDevelopmental Biology