Author

Bryan N. Brown

University of PittsburghORCID 0000-0002-0845-7828Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 3 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:imaging· 2 Organism:rat· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Devora Cohen-KarniiD· 2 shared Liyang WangiD· 2 shared Samuel A. GershanokiD· 2 shared Stephen F. BadylakiD· 2 shared Tzahi Cohen‐KarniiD· 2 shared Adam W. FeinbergiD· 1 shared Alpaslan ErsöziD· 1 shared Anne BehreiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersBioengineering

Devora Cohen-KarniORCID

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Author profile →

4 papers

Recent·Most cited

Early electrical stimulation promotes functional recovery after volumetric muscle loss

Samuel A. Gershanok, Anne Behre, Rifeng Jin, Sofya Vinokurova, John Blount, Raghav Garg, Alpaslan Ersöz, Liyang Wang, Seonghan Jo, Daniel Ranke, Mangesh M. Kulkarni, Devora Cohen-Karni, Adam W. Feinberg, DJ Weber, Bryan N. Brown, Tzahi Cohen‐Karni

This study shows that early electrical stimulation improves functional recovery in rats with volumetric muscle loss by enhancing muscle remodeling.

bioRxiv · May 12, 2026 · PreprintBioengineering

Macrophage-to-Myofibroblast Transition (MMT)- an adverse response to polypropylene mesh implanted for pelvic organ prolapse repair surgery in a non-human primate model

Marrisa A. Therriault, Katrina M. Knight, Srividya Kottapalli, Temitope Obisesan, Malini Harinath, Bryan N. Brown, Pamela Moalli

This study investigates how mesh deformation and tension affect macrophage-to-myofibroblast transition (MMT) and host response in a non-human primate model of pelvic organ prolapse repair.

Biomaterials · Nov 20, 2025Peer-reviewedBioengineering

Wound state monitoring by multiplexed, electrochemical, real-time, localized, inflammation-tracking nitric oxide sensor (MERLIN)

Liyang Wang, Yingqiao Wang, Mabel Bartlett, Daniel San Roman, Gaurav Balakrishnan, Samuel A. Gershanok, Reem Khan, Clint D. Skillen, Shanae Butler, Mangesh S. Kulkarni, Stephen F. Badylak, Devora Cohen-Karni, Bryan N. Brown, Tzahi Cohen‐Karni

The paper introduces MERLIN, a sensor for real-time, localized NO detection in wounds, showing NO peaks on day 3 post-injury in rat models.

Science Advances · May 28, 2025Peer-reviewedBioengineering

Transcriptomic Landscape and Immune Microenvironment AroundWound Bed Define Regenerative versus Non-regenerative Outcomesin Mouse Digit Amputation

Archana Prabahar, Connie S. Chamberlain, Ray Vanderby, William L. Murphy, William D’Angelo, Kulkarni Mangesh, Bryan N. Brown, Barsanjit Mazumder, Stephen F. Badylak, Peng Jiang

The paper investigates regenerative versus non-regenerative outcomes after mouse digit amputation by analyzing the wound bed's transcriptomic landscape and immune microenvironment, identifying key transcription factors and developing a predictive AI model.

bioRxiv · Dec 4, 2024 · PreprintDevelopmental Biology