Red yeast rice-derived MKA ameliorates cardiac hypertrophy in hypertensive rats by inhibiting ERK1/2/c-Fos pathway
Rubin Tan, Dongqi Yang, Kuntao Liu, Jia LIU, Na Li, Manqi Sun, Xiaoqiu Tan, Qinghua Hu, Chunxiang Zhang
This study shows that MKA from red yeast rice reduces cardiac hypertrophy in hypertensive rats by inhibiting the ERK1/2/c-Fos pathway, with no organ toxicity and transgenerational benefits.
bioRxiv · Mar 13, 2026 · PreprintPharmacology & Toxicology