Rational design of HER2-targeted combination therapies to reverse drug resistance in fibroblast-protected HER2+ breast cancer cells.
Matthew D. Poskus, Jacob McDonald, Matthew S. Laird, Ruxuan Li, Kyle Norcoss, Ioannis K. Zervantonakis
This study identifies PAI1 and PLK1 as predictors of fibroblast-mediated resistance in HER2+ breast cancer and shows that targeting these proteins with lapatinib improves treatment efficacy.
Cellular and Molecular Bioengineering · Oct 1, 2024Peer-reviewedBioengineering