Author

Matthew D. Poskus

University of PittsburghORCID 0000-0003-3633-0987Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Ioannis K. ZervantonakisiD· 2 shared Jacob McDonald· 1 shared Kyle Norcoss· 1 shared Matthew S. LairdiD· 1 shared Mohammadmahdi EskandarisaniiD· 1 shared Ruxuan LiiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 11 mutual co-author links

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2 shared papersBioengineering

Ioannis K. ZervantonakisORCID

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2 papers

Recent·Most cited

BioengineeringbioRxivPreprintDec 22, 2025

Hydrogel array patterning using 3D-printed microfluidic inserts to control cell-cell and cell-ECM interactions

Matthew D. Poskus, Mohammadmahdi Eskandarisani, Ioannis K. Zervantonakis

This paper introduces a 3D-printed microfluidic insert to pattern hydrogel arrays and generate gradients, enabling study of cell-cell and cell-ECM interactions in 3D microenvironments.

DOI 10.64898/2025.12.21.695682

humanexperimental assay

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BioengineeringCellular and Molecular BioengineeringPeer-reviewedOct 1, 2024

Rational design of HER2-targeted combination therapies to reverse drug resistance in fibroblast-protected HER2+ breast cancer cells.

Matthew D. Poskus, Jacob McDonald, Matthew S. Laird…·Ioannis K. Zervantonakis

This study identifies PAI1 and PLK1 as predictors of fibroblast-mediated resistance in HER2+ breast cancer and shows that targeting these proteins with lapatinib improves treatment efficacy.

1 citation

humanproteomics

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