Ruxuan Li

This study shows that chronic inflammation and hormonal changes in older women create a tumor-permissive environment for ER+ breast cancer by increasing local estradiol and immune dysfunction.

The paper identifies S100A11 as a factor promoting macrophage recruitment in ER+ breast cancer through single-cell RNA-sequencing analysis and functional experiments.

This study identifies PAI1 and PLK1 as predictors of fibroblast-mediated resistance in HER2+ breast cancer and shows that targeting these proteins with lapatinib improves treatment efficacy.

This study uses a microwell platform to analyze CAR T cell infiltration and cytotoxicity in 3D breast cancer spheroids, identifying factors like spheroid size and seeding density that influence anti-tumor activity.