Molecular BiologyNature CommunicationsPeer-reviewed
WRN Inhibition Leads to its Chromatin-Associated Degradation Via the PIAS4-RNF4-p97/VCP Axis
Fernando Rodríguez-Pérez, Dean E. Natwick, Lauren Schiff…·Stephen E. Basham
This study identifies a novel regulatory mechanism for WRN degradation via the PIAS4-RNF4-p97/VCP axis in MSI-H cancer cells using single molecule tracking and inhibitor screening.
22 citations