Backbone Thioamide Substitution Enhances the Activity of Short Peptides in Modulating the Aggregation of α-Synuclein
Haoliang Zheng, Kyren Miller, Magdalena I. Ivanova, Robert W. Newberry
This study shows that modifying the backbone of a minimal NAC-derived peptide with thioamide enhances its ability to modulate α-synuclein aggregation, while N-methylation inhibits it.
bioRxiv · Aug 26, 2026 · PreprintBiochemistry