Elexacaftor/Tezacaftor/Ivacaftor alters branching morphogenesis of the mouse embryonic lung
M. Lhuillier, L. Aoust, E. Dreano, M.-L. Franco-Montoya, K. Landry-Truchon, N. Houde, S. Chhun, A. Hinzpeter, A. Edelman, C. Delacourt, L. Jeannotte, I. Sermet-Gaudelus, A. Hadchouel Duverge
This paper shows that the triple CFTR modulator therapy ETI reduces lung branching and increases terminal bud dilation in mouse embryos, suggesting potential developmental risks.
bioRxiv · Nov 1, 2021 · PreprintPharmacology & Toxicology