Repression of MUC1 promotes expansion and suppressive function of myeloid-derived suppressor cells in pancreatic ductal adenocarcinoma and breast cancer murine models.
M. Sahraei, L. Das Roy, M. Bose, C. De, S. Nath, P. Mukherjee
This study shows that MUC1 repression in MDSCs enhances their proliferation and suppressive function in pancreatic and breast cancer models, leading to increased tumor growth and immune suppression.
bioRxiv · Dec 7, 2020Cancer Biology