Evolvability of cancer-associated genes under APOBEC3A/B selection
J.-H. Song, L. Davalos, T. MacCarthy, M. Damaghi
The paper investigates how APOBEC3A/B activity influences the evolvability of cancer-associated genes compared to non-cancer genes across humans and bats, finding bimodal mutation patterns and increased cancer heterogeneity.
bioRxiv · Aug 27, 2023Cancer Biology