Author

M. Damaghi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 9 Evolutionary Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:statistical model· 7 Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:clustering· 2 Assay:imaging· 2 Assay:proteomics· 2

Frequent Co-Authors

R. J. Gillies· 5 shared J. West· 3 shared M. Robertson-Tessi· 3 shared R. Gatenby· 3 shared A. Anderson· 2 shared A. Ibrahim-Hashim· 2 shared J. A. Gallaher· 2 shared J. S. Brown· 2 shared

Activity by Year

2018-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersCancer Biology

R. J. Gillies

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Evolvability of cancer-associated genes under APOBEC3A/B selection

J.-H. Song, L. Davalos, T. MacCarthy, M. Damaghi

The paper investigates how APOBEC3A/B activity influences the evolvability of cancer-associated genes compared to non-cancer genes across humans and bats, finding bimodal mutation patterns and increased cancer heterogeneity.

bioRxiv · Aug 27, 2023Cancer Biology

Adaptive therapy for ovarian cancer: An integrated approach to PARP inhibitor scheduling

M. Strobl, A. Martin, J. West, J. Gallaher, M. Robertson-Tessi, R. Gatenby, R. Wenham, P. Maini, M. Damaghi, A. R. A. Anderson

This study develops an adaptive therapy protocol for PARP inhibitors by combining mathematical modeling and experiments to optimize treatment scheduling and mitigate resistance.

bioRxiv · Mar 22, 2023 · PreprintCancer Biology

Cycling hypoxia selects for constitutive HIF stabilization

M. Pressley, J. A. Gallaher, J. S. Brown, M. R. Tomaszewski, P. Borad, M. Damaghi, R. J. Gillies, C. J. Whelan

The paper develops a mathematical model showing that rapid oxygen fluctuations favor pseudohypoxia by selecting for constitutive HIF stabilization despite reduced cell fitness.

bioRxiv · Oct 28, 2020Cancer Biology

Omics integration analyses reveal the early evolution of malignancy in breast cancer

S. Sarhadi, A. Salehzadeh-Yazdi, M. Damaghi, N. Zarghami, O. Wolkenhauer, H. Hosseini

This study integrates omics data from breast cancer to show that malignancy evolves through genetic fine-tuning rather than de novo pathways in both pre-invasive and invasive stages.

bioRxiv · Apr 9, 2020Evolutionary Biology

The Harsh Microenvironment in Early Breast Cancer Selects for a Warburg Phenotype

M. Damaghi, J. West, M. Robertson-Tessi, L. Xu, M. C. Ferrall-Fairbanks, P. A. Stewart, E. A. Persi, B. L. Fridley, P. M. Altrock, R. Gatenby, p. A. Sims, A. R. Anderson, R. J. Gillies

The paper investigates how harsh microenvironments in early breast cancer select for a Warburg phenotype through metabolic and transcriptomic changes.

bioRxiv · Apr 7, 2020Cancer Biology

Frequency-dependent interactions determine outcome of competition between two breast cancer cell lines

A. R. Freischel, M. Damaghi, J. J. Cunningham, A. Ibrahim-Hashim, R. J. Gillies, R. A. Gatenby, J. S. Brown

This study shows that competition between two breast cancer cell lines depends on frequency-dependent interactions, not just growth rates or carrying capacities.

bioRxiv · Mar 6, 2020Cancer Biology

Turnover modulates the need for a cost of resistance in adaptive therapy

M. A. R. Strobl, J. West, Y. Viossat, M. Damaghi, M. Robertson-Tessi, J. Brown, R. Gatenby, P. Maini, A. Anderson

This study investigates whether a cost of resistance is necessary for adaptive therapy to delay cancer progression, finding that cell turnover modulates this requirement depending on tumor growth conditions.

bioRxiv · Jan 22, 2020Cancer Biology

Mix & Match: Phenotypic coexistence as a key facilitator of solid tumour invasion

M. A. R. Strobl, A. L. Krause, M. Damaghi, r. j. gillies, A. Anderson, P. K. Maini

This study uses a mathematical model to show that stable coexistence of different cancer cell phenotypes enhances tumour invasion by allowing complementary traits to work synergistically.

bioRxiv · Aug 30, 2019Cancer Biology

Collagen Production and Niche Engineering: A Novel Strategy for Cancer Cells to Survive Acidosis and Evolve

M. Damaghi, S. Byrne, L. Xu, N. Tafreshi, B. Fang, J. Koomen, A. Karolak, T. Chen, J. Johnson, N. Gallant, A. Marusyk, R. J. Gillies

The paper identifies collagen production as an adaptation strategy in acidotic cancer cells, showing correlation with patient survival.

bioRxiv · Jul 24, 2019Cancer Biology

Lymph Nodes Inhibit T-cell Effector Functions Locally by Establishing Acidic Niches

H. Wu, V. Estrella, P. Enriquez-Navas, A. El-Kenawi, S. Russell, D. Abrahams, A. Ibrahim-Hashim, D. Longo, Y. Reshetnyak, K. Luddy, M. Damaghi, S. R. Pillai, M. Beatty, S. Pilon-Thomas, P. Swietach, r. gillies

The paper shows that acidic niches in lymph nodes inhibit T-cell effector functions by blocking lactic acid efflux and reducing glycolysis, keeping T-cells in a state of stasis.

bioRxiv · Jul 2, 2019 · PreprintPhysiology

Connecting the Microenvironmental Niche to Treatment Response in Ovarian Cancer

M. Strobl, M. Wicker, V. Adhikarla, A. Shockey, E. Lakatos, P. Pooladvand, R. Schenck, L. Saputro, C. Gatenby, M. Koppens, S. Cruz Garcia, R. Wenham, M. Damaghi, J. A. Gallaher

This study develops a mathematical model to analyze spatial interactions in ovarian cancer microenvironments and shows how niche composition affects treatment response.

bioRxiv · Oct 24, 2018 · PreprintCancer Biology