Author

L. E. H. Smith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Das· 1 shared A. Dubrac· 1 shared A. Kuo· 1 shared A. Situ· 1 shared B. Jung· 1 shared B. Maranda· 1 shared C. B. Clish· 1 shared C. Betus· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

A. Das

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Author profile →

2 papers

Recent·Most cited

Metabolic Reprogramming of the Neovascular Niche Promotes Regenerative Angiogenesis in Proliferative Retinopathy

G. Cagnone, S. Pundir, J. Sung-Kim, J. C. Rivera, T. Agnihotri, N.-R. Harvey, E. Heckel, C. Betus, M. X. Chen, A. Situ, P. Gaub, N. Kim, A. Das, S. Leclerc, F. Wunnemann, , J.-S. Joyal

This study shows that metabolic reprogramming in the neurovascular niche promotes regenerative angiogenesis in proliferative retinopathy by shifting metabolism from fatty acid oxidation to glycolysis.

bioRxiv · Nov 13, 2023Cell Biology

Therapeutic activation of endothelial sphingosine 1-phosphate receptor-1 by chaperone-bound S1P suppresses proliferative retinal vasculopathy

C. Niaudet, B. Jung, A. Kuo, S. Swendeman, E. Bull, T. Seno, R. Crocker, Z. Fu, L. E. H. Smith, T. Hla

The paper shows that activating endothelial S1PR1 with HDL-bound S1P or a Gi-biased agonist suppresses neovascular tufts in retinopathy models.

bioRxiv · Jun 14, 2022 · PreprintPathology