C. B. Clish

Ether lipids influence cancer cell fate by modulating iron uptake

This study shows that ether lipids in cancer cells regulate membrane properties to influence iron uptake, ferroptosis, and metastasis, offering a therapeutic target.

Vaginal Lactobacillus fatty acid response mechanisms reveal a novel strategy for bacterial vaginosis treatment

This study identifies oleic acid as a compound that inhibits L. iners and promotes L. crispatus growth, offering a potential new treatment strategy for bacterial vaginosis.

Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability

This study profiles metabolites in renal cell carcinoma tissue and fluid to show that nutrient availability is more influenced by tissue-specific factors than tumor-driven changes.

Metabolic Reprogramming of the Neovascular Niche Promotes Regenerative Angiogenesis in Proliferative Retinopathy

This study shows that metabolic reprogramming in the neurovascular niche promotes regenerative angiogenesis in proliferative retinopathy by shifting metabolism from fatty acid oxidation to glycolysis.

Lac-Phe mediates the anti-obesity effect of metformin

This study identifies Lac-Phe as a mediator of metformin's anti-obesity effects through experiments in mice and human cohorts.

Beneficial metabolic effects of PAHSAs depend on the gut microbiota in diet-induced obese mice

This study shows that PAHSAs improve insulin sensitivity in diet-induced obese mice via the gut microbiota, with sex-specific effects observed.

Identification and targeting of microbial putrescine acetylation in bloodstream infections

The paper identifies bacterially-derived N-acetylputrescine as a marker of severe gram-negative bloodstream infections and shows that inhibiting its synthesis reduces bacterial growth and antibiotic resistance.

Early cellular and molecular signatures correlate with severity of West Nile Virus infection

The paper identifies cellular and molecular signatures associated with varying severities of West Nile Virus infection using multi-omics analysis of immune responses.

Screening in serum-derived medium reveals differential response to compounds targeting metabolism

The paper screens compounds targeting metabolism in serum-derived medium to identify differential responses in cancer cells, aiming to improve drug response prediction.

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity

FALCON systematically analyzes 61 free fatty acids to identify lipotoxic effects and a novel mediator of lipotoxicity, CMIP, in human pancreatic beta cells.

Effectors enabling adaptation to mitochondrial complex I loss in Hurthle cell carcinoma

This study identifies molecular effectors in Hurthle cell carcinoma linked to mitochondrial complex I loss, highlighting lipid peroxide scavenging as a therapeutic vulnerability.

Plasma and ovarian metabolomics responses to chronic stress in female mice

This study identifies differences in plasma and ovarian metabolomics in female mice under chronic stress, showing opposite associations for some metabolites between systemic and tissue-specific contexts.

Human gut bacteria produce TH17-modulating bile acid metabolites

This study identifies human gut bacteria that produce TH17-modulating bile acid metabolites, showing reduced levels in IBD patients.

Metabolomic profiling identifies complex lipid species associated with response to weight loss interventions

The paper identifies metabolites, particularly lipids, associated with response to weight loss interventions and highlights their role in metabolic heterogeneity.

Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1

This study shows that pancreatic cancer cells can adapt to nutrient deprivation by stabilizing glutamine synthetase via mTORC1, and this adaptation is reversible.