Structural and Dynamic Basis of Molecular Recognition between Acyltransferase and Carrier Protein in E. coli Fatty Acid Synthesis
L. E. Misson, J. T. Mindrebo, T. D. Davis, A. Patel, J. A. McCammon, J. P. Noel, M. D. Burkart
This study determines the structure and dynamics of ACP-AT interactions in E. coli FAS using crystallography, MD simulations, and biochemical analyses, revealing flexible conformations and subdomain motions critical for catalysis.
bioRxiv · May 15, 2020 · PreprintBiochemistry