Neutrophil Peptidylarginine Deiminase 4 is Essential for Detrimental Age-related Cardiac Remodeling and Dysfunction in Mice
S. Van Bruggen, S. Kraisin, J. Van Wauwe, P. Carai, L. Frederix, T. Witsch, K. Martinod
This study shows that neutrophil PAD4 deletion protects against age-related cardiac dysfunction and fibrosis in mice by affecting the CXCL1-CXCR2 axis.
bioRxiv · Mar 14, 2022 · PreprintPhysiology