Author

L. Genovese

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Approach:deep learning· 4 Research Focus:protein folding & dynamics· 4 Approach:statistical model· 4 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1

Frequent Co-Authors

B. Momeni· 4 shared M. Zaccaria· 4 shared T. Nakajima· 4 shared W. Dawson· 4 shared D. R. Kish· 2 shared L. Dellafiora· 2 shared M. Domin· 2 shared M. Farzan· 2 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersBiophysics

B. Momeni

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Author profile →

4 papers

Recent·Most cited

Mechanistic investigation of SARS-CoV-2 Omicron variant spike mutants via full quantum mechanical modeling

M. Zaccaria, L. Genovese, B. Lawhorn, W. Dawson, A. S. Joyal, J. Hu, P. Autissier, T. Nakajima, W. E. Johnson, I. Fofana, M. Farzan, B. Momeni

The paper uses quantum mechanical modeling to predict and analyze binding strengths of SARS-CoV-2 spike variants to the human ACE2 receptor, validating predictions experimentally.

bioRxiv · Dec 1, 2021Biophysics

Anticipating future SARS-CoV-2 variants of concern through ab initio quantum mechanical modeling

M. Zaccaria, L. Genovese, M. Farzan, W. Dawson, T. Nakajima, W. E. Johnson, B. Momeni

This paper uses quantum mechanical modeling to predict the impact of SARS-CoV-2 mutations on hACE2 binding and identify potential future variants of concern.

bioRxiv · Nov 25, 2021Biophysics

Mechanistic Insight from Full Quantum Mechanical Modeling: Laccase as a Detoxifier of Aflatoxins

M. Zaccaria, W. Dawson, D. R. Kish, M. Reverberi, M. C. Bonaccorsi di Patti, M. Domin, V. Cristiglio, L. Dellafiora, F. Gabel, T. Nakajima, L. Genovese, B. Momeni

The paper uses quantum mechanical modeling to show that low steric affinity, not oxidative activity, limits laccase's ability to detoxify aflatoxins, identifying key residues for enzyme optimization.

bioRxiv · Dec 31, 2020 · PreprintBiophysics

Full quantum mechanical modeling of the enzyme-substrate system: how laccase detoxifies aflatoxin

M. Zaccaria, W. Dawson, D. R. Kish, M. Reverberi, M. Domin, L. Dellafiora, T. Nakajima, L. Genovese, B. Momeni

This paper uses quantum mechanical modeling to study laccase detoxification of aflatoxin, identifying affinity limitations and environmental dependencies, and proposes a roadmap for enzyme optimization.

bioRxiv · Mar 2, 2020 · PreprintBiophysics