Activated αIIbβ3 on platelets mediates flow-dependent NETosis via SLC44A2
A. Constantinescu-Bercu, L. Grassi, M. Frontini, I. I. Salles-Crawley, K. J. Woollard, J. T. Crawley
The paper shows that activated platelet integrin IIbβ3 mediates flow-dependent neutrophil extracellular trap formation via SLC44A2, with a polymorphism in SLC44A2 protecting against venous thrombosis.
bioRxiv · Oct 25, 2019 · PreprintCell Biology