Proteolytic cleavage of the extracellular domain affects signaling of parathyroid hormone receptor 1
C. Klenk, L. Hommers, M. J. Lohse
This study identifies the cleavage site of the PTH1R extracellular domain and shows that proteolytic cleavage alters receptor signaling specificity by reducing Gs activation and increasing Gq activation.
bioRxiv · Dec 16, 2021Pharmacology & Toxicology