Activity modulation in anaerobic ribonucleotide reductases: nucleotide binding to the ATP-cone allosterically mediates substrate binding to the active site
O. Bimai, I. Banerjee, I. R. Grinberg, P. Huang, L. Hultgren, S. Ekström, D. Lundin, B.-M. Sjöberg, D. T. Logan
This study investigates how ATP and dATP binding to the ATP-cone of anaerobic RNR from Prevotella copri modulates enzyme activity through structural and biochemical changes.
bioRxiv · Jun 20, 2023Biochemistry