Author

L. J. Lapidus

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Approach:deep learning· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

M. Feig· 3 shared G. Valdes-Garcia· 2 shared L. Heo· 2 shared A. A. Ashkarran· 1 shared B. Dutagaci· 1 shared C. G. Hoogstraten· 1 shared G. Nawrocki· 1 shared J. Goodluck· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 21 mutual co-author links

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3 shared papersBiophysics

M. Feig

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3 papers

Recent·Most cited

Modeling concentration-dependent phase separation processes involving peptides and RNA via residue-based coarse-graining

G. Valdes-Garcia, L. Heo, L. J. Lapidus, M. Feig

The paper introduces a residue-based coarse-grained model, COCOMO, to simulate concentration-dependent phase separation of peptides and RNA, showing it predicts experimental data and is computationally efficient.

bioRxiv · Aug 19, 2022Biophysics

Characterizing Transient Protein-Protein Interactions by Trp-Cys Quenching and Computer Simulations

L. Heo, K. Gamage, G. Valdes-Garcia, L. J. Lapidus, M. Feig

This paper introduces Trp-Cys quenching experiments combined with simulations to study transient protein interactions under crowded conditions, showing they can distinguish interaction types and preferences.

bioRxiv · Aug 5, 2022Biophysics

Charge-Driven Phase Condensation of RNA and Proteins Suggests Broad Role of Phase Separation in Cytoplasmic Environments

B. Dutagaci, G. Nawrocki, J. Goodluck, A. A. Ashkarran, C. G. Hoogstraten, L. J. Lapidus, M. Feig

This study shows that RNA and positively charged proteins can form phase-separated condensates through electrostatic complementarity, suggesting a broad role of phase separation in cytoplasmic environments.

bioRxiv · Apr 23, 2020Biophysics