Evolution of a Functionally Intact but Antigenically Distinct DENV Fusion Loop
R. M. Meganck, D. Zhu, S. Dong, L. J. Snoderly-Foster, Y. R. Dalben, D. J. Thiono, L. J. White, A. M. DeSilva, R. Baric, L. V. Tse
This study engineers DENV variants with mutated fusion loops that evade neutralizing antibodies but retain sensitivity to cross-reactive antibodies, offering tools for vaccine development.
bioRxiv · Mar 22, 2023 · PreprintMicrobiology