Author

L. Kobrossy

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Biology Disciplines

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Cancer Biology· 1

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Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

C. E. Turner· 1 shared C. Zhang· 1 shared M. S. Cosgrove· 1 shared W. Feng· 1 shared W. Xu· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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1 shared paperCancer Biology

C. E. Turner

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1 paper

Recent·Most cited

Unraveling MLL1-fusion Leukemia: Epigenetic Revelations from an iPS Cell Point Mutation

L. Kobrossy, W. Xu, C. Zhang, W. Feng, C. E. Turner, M. S. Cosgrove

This study introduces a point mutation in MLL1 in iPS cells to mimic MLL1F-LSCs phenotypes, revealing that loss of MLL1 enzymatic activity drives H3K4 trimethylation via mislocalized SETd1a.

Journal of Biological Chemistry · Nov 1, 2024Peer-reviewedCancer Biology