C. E. Turner

Unraveling MLL1-fusion Leukemia: Epigenetic Revelations from an iPS Cell Point Mutation

This study introduces a point mutation in MLL1 in iPS cells to mimic MLL1F-LSCs phenotypes, revealing that loss of MLL1 enzymatic activity drives H3K4 trimethylation via mislocalized SETd1a.

Molecular characterisation of Streptococcus pyogenes (StrepA) non-invasive isolates during the 2022-23 UK upsurge

This study characterizes non-invasive Streptococcus pyogenes isolates from a 2022-23 UK scarlet fever upsurge, revealing strain diversity and genomic features associated with different infection types.

Multiple evolutionary pathways lead to vancomycin resistance in Clostridioides difficile

This study shows that C. difficile can evolve vancomycin resistance through two pathways, but resistance comes with fitness costs and sporulation defects that may limit its clinical impact.

CD9 co-operation with syndecan-1 is required for a major staphylococcal adhesion pathway

This study shows CD9 and syndecan-1 cooperate for staphylococcal adhesion, with fibronectin also playing a role, and suggests CD9-targeted therapies could block bacterial entry.

Characterisation of emergent toxigenic M1UK Streptococcus pyogenes and associated sublineages

This study characterizes the M1UK sublineage of Streptococcus pyogenes, identifying genetic and phenotypic differences that contribute to its dominance and increased virulence.

Comparative genomic analysis of skin and soft tissue Streptococcus pyogenes isolates from low- and high-income settings

This study compares the genomes of Streptococcus pyogenes isolates from low- and high-income settings, revealing genetic diversity and differences in resistance genes and prophage content.

Antibody Activities in Hyperimmune Plasma Against the Rhodococcus equi Virulence -Associated Protein A or Poly-N-Acetyl Glucosamine are Associated with Protection of Foals Against Rhodococcal Pneumonia

This study assesses the protective efficacy of hyperimmune plasma against Rhodococcus equi pneumonia in foals by analyzing antibody activities against specific antigens.

Vaccine-induced, but not natural immunity, against the Streptococcal Inhibitor of Complement protects against invasive disease

This study shows that vaccine-induced antibodies against SIC provide protection against invasive S. pyogenes infection, while natural antibodies do not.

Cryptic prophages within a Streptococcus pyogenes genotype emm4 lineage

This study identifies a cryptic prophage lineage in emm4 Streptococcus pyogenes isolates, showing gene loss and reduced inducibility compared to other strains.

The emergence of successful Streptococcus pyogenes lineages through convergent pathways of capsule loss and recombination directing high toxin expression

The paper identifies convergent evolutionary pathways in Streptococcus pyogenes lineages through recombination at the nga-slo locus and capsule loss, associated with increased toxin expression and disease success.

Streptococcal superantigen-induced expansion of human tonsil T cells leads to altered T follicular helper cell phenotype, B cell death, and reduced immunoglobulin release

This study shows that streptococcal superantigens alter T follicular helper cell phenotype, induce B cell death, and reduce immunoglobulin release in human tonsil cells.