Author

L. Lagardere

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:mechanistic / dynamical model· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

J.-P. Piquemal· 3 shared A. JEGOU· 1 shared A. Schahl· 1 shared B. Walker· 1 shared F. Bregier· 1 shared F. Celerse· 1 shared H. Wioland· 1 shared J. Godard· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBiophysics

J.-P. Piquemal

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3 papers

Recent·Most cited

High-resolution Molecular Dynamics Simulations of the Pyruvate Kinase Muscle Isoform 1 and 2 (PKM1/2)

Q. Delobelle, T. Jaffrelot-Inizan, O. P. Adjoua, L. Lagardere, F. Celerse, V. Marechal, J.-P. Piquemal

This study uses high-resolution molecular dynamics simulations to analyze PKM1 and PKM2 structural dynamics, revealing new cryptic pockets for antitumoral drug design.

bioRxiv · Jan 7, 2024Biophysics

Enforcing local DNA kinks by sequence-selective trisintercalating oligopeptides of a tricationic porphyrin. A polarizable Molecular Dynamics study.

N. Gresh, K. El Hage, L. Lagardere, F. Bregier, J. Godard, J.-P. Piquemal, M. Perree-Fauvet, V. Sol

This paper uses molecular dynamics to show that BABAP derivatives induce sequence-selective DNA kinks, mimicking DNA-bound Cre recombinase structures.

bioRxiv · Jul 26, 2023Biophysics

Histidine 73 methylation coordinates ????-actin plasticity in response to key environmental factors

A. Schahl, L. Lagardere, B. Walker, P. Ren, H. Wioland, M. Ballet, A. JEGOU, M. Chavent, J.-P. Piquemal

This study uses molecular dynamics simulations to show that H73 methylation in β-actin affects nucleotide binding, allosteric pathways, and phosphate release, regulating actin plasticity in response to environmental factors.

bioRxiv · Dec 16, 2022Biophysics