Author

H. Wioland

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Biochemistry· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 6 Approach:experimental assay· 6 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

A. Jegou· 8 shared G. Romet-Lemonne· 7 shared B. Guichard· 2 shared A. Burnetti· 1 shared A. Echard· 1 shared A. R. Honerkamp-Smith· 1 shared A. Schahl· 1 shared B. Walker· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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8 shared papersBiophysics

A. Jegou

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Fascin-induced bundling protects actin filaments from disassembly by cofilin

J. Chikireddy, L. Lengagne, R. Le Borgne, H. Wioland, G. Romet-Lemonne, A. Jegou

This study shows that fascin crosslinking slows cofilin-induced actin filament disassembly by reducing cofilin cluster nucleation on bundles, while promoting inter-filament cooperativity.

bioRxiv · May 19, 2023Biochemistry

Histidine 73 methylation coordinates ????-actin plasticity in response to key environmental factors

A. Schahl, L. Lagardere, B. Walker, P. Ren, H. Wioland, M. Ballet, A. JEGOU, M. Chavent, J.-P. Piquemal

This study uses molecular dynamics simulations to show that H73 methylation in β-actin affects nucleotide binding, allosteric pathways, and phosphate release, regulating actin plasticity in response to environmental factors.

bioRxiv · Dec 16, 2022Biophysics

Cellular organization in lab-evolved and extant multicellular species obeys a maximum entropy law

T. C. Day, S. S. Höhn, S. A. Zamani-Dahaj, D. Yanni, A. Burnetti, J. Pentz, A. R. Honerkamp-Smith, H. Wioland, H. R. Sleath, W. C. Ratcliff, R. E. Goldstein, P. J. Yunker

The paper quantifies cell packing in two multicellular organisms and finds that free space around cells follows a gamma distribution, suggesting an entropic principle underlying multicellular organization.

bioRxiv · Jul 29, 2021Biophysics

Dynamics of Tpm1.8 domains on actin filaments with single moleculeresolution

I. Bareja, H. Wioland, M. Janco, P. R. Nicovich, A. JEGOU, G. Romet-Lemonne, J. Walsh, T. Boecking

This study uses fluorescence microscopy and modeling to quantify Tpm1.8 binding kinetics on actin filaments, revealing independent decoration of actin strands and asymmetric domain dynamics.

bioRxiv · Jun 15, 2020Biophysics

Actin filament oxidation by MICAL1 suppresses protections from cofilin-induced disassembly

H. Wioland, S. Fremont, B. Guichard, A. Echard, A. JEGOU, G. Romet-Lemonne

This study shows that MICAL1-induced actin filament oxidation enhances cofilin binding and severing, bypassing the need for cofilin activation and overcoming tropomyosin protection.

bioRxiv · Feb 26, 2020Biochemistry

Twinfilin uncaps filament barbed ends to promote turnover of lamellipodial actin networks

M. Hakala, H. Wioland, M. Tolonen, A. Jegou, G. Romet-Lemonne, P. Lappalainen

This study identifies twinfilin as a regulator of capping protein dynamics in actin networks, showing it promotes CP dissociation and filament turnover in cells.

bioRxiv · Dec 4, 2019Cell Biology

Quantitative variations of ADF/cofilin’s multiple actions on actin filaments with pH

H. Wioland, A. Jegou, G. Romet-Lemonne

This paper quantifies how ADF/cofilin's actions on actin filaments change with pH, showing that pH affects filament severing rates but not severing per domain boundary, and that barbed-end depolymerization remains unstoppable at physiological pH.

bioRxiv · Sep 20, 2018Biochemistry

Torsional stress generated by ADF/cofilin on cross-linked actin filaments boosts their severing

H. Wioland, A. Jegou, G. Romet-Lemonne

This study shows that ADF/cofilin-induced torsional stress enhances actin filament severing in cross-linked networks by increasing the severing rate constant 100-fold.

bioRxiv · Jul 31, 2018Biophysics

Modulation of formin processivity by profilin and mechanical tension

M. Kerleau, L. Cao, E. Suzuki, H. Wioland, S. Jouet, B. Guichard, M. Lenz, G. Romet-Lemonne, A. Jegou

This study investigates how profilin and mechanical tension modulate formin mDia1 processivity by altering dissociation rates from actin filaments.

bioRxiv · Dec 16, 2017Biophysics