Cytotoxic CD4+ T cells driven by T-cell intrinsic IL-18R/MyD88 signaling predominantly infiltrate Trypanosoma cruzi-infected hearts
C.-H. D. Barbosa, F. B. Canto, A. Gomes, L. M. Brandao, J. R. Lima, G. A. Melo, A. Granato, E. G. Neves, A.-C. Oliveira, W. O. Dutra, A. Nobrega, M. Bellio
This study identifies CD4+ T cells with cytotoxic activity as key players in immunity against Trypanosoma cruzi, showing their dependence on T-cell intrinsic IL-18R/MyD88 signaling.
bioRxiv · Oct 21, 2021Immunology