Epistatic interactions shape the interplay between beneficial alleles and gain or loss of pathways in the evolution of novel metabolism
E. L. Bruger, L. M. Chubiz, J. I. Rojas Echenique, C. J. Renshaw, N. V. Espericueta, J. A. Draghi, C. J. Marx
The paper investigates how epistatic interactions affect the fitness of beneficial alleles in different genetic backgrounds, showing that alleles beneficial in one context can be deleterious in others, impacting the evolution of novel metabolic pathways.
bioRxiv · Oct 20, 2020 · PreprintEvolutionary Biology