How PTEN mutations degrade function at the membrane and life expectancy of carriers of mutations in the human brain
H. JANG, J. Chen, L. M. Iakoucheva, R. Nussinov
This study investigates how PTEN mutations affect conformational dynamics and clinical outcomes, revealing differences in catalytic activity and life expectancy between neurodevelopmental disorder and cancer-related mutations.
bioRxiv · Jan 26, 2023 · PreprintBiophysics