H. Jang

Whole-body PET imaging of SIV using anti-Env probes fails to reveal regions of specific uptake in rhesus macaques

This study evaluates two anti-gp120 antibodies for immunoPET imaging of SIV in rhesus macaques and finds no specific uptake, suggesting inadequate binding potential for in vivo imaging.

A spatially resolved multiomic single-cell atlas of soybean development

The paper constructs a spatially resolved multiomic single-cell atlas of soybean development, identifying cell types, chromatin regions, and gene regulatory networks involved in growth and nitrogen fixation.

Woman the Hunter? Female foragers sometimes hunt, yet gendered divisions of labor are real

The paper critiques a study claiming foraging societies lack gendered labor divisions, finding methodological flaws and emphasizing the importance of broader labor roles.

BaYaka mothers balance childcare and subsistence tasks during collaborative foraging in Congo Basin

The paper examines how BaYaka mothers balance childcare and foraging tasks in Congo Basin, finding that infant presence does not limit travel distance or food returns but increases group foraging efficiency.

Evolution of plant cell-type-specific cis-regulatory elements

The paper constructs a single-cell chromatin accessibility atlas in rice and compares it across grass species to study the evolution of cell-type-specific cis-regulatory elements.

Dynamic evolution of the heterochromatin sensing histone demethylase IBM1

This study investigates the evolution of IBM1, an H3K9 demethylase, in flowering plants, showing its role in regulating gene body methylation and its dynamic evolution across species.

Regulator of Chromosome Condensation (RCC1) a novel therapeutic target in pancreatic ductal adenocarcinoma drives tumor progression via the c-Myc-RCC1-Ran axis

This study identifies RCC1 as a novel therapeutic target in PDAC, showing its role in tumor progression and drug resistance through the c-Myc-RCC1-Ran axis.

Molecular Mechanism of Regulation of RhoA GTPase by Phosphorylation of RhoGDI

This study investigates how phosphorylation of RhoGDI regulates RhoA GTPase activation through molecular dynamics simulations and binding free energy calculations.

Host-Microbiome Associations in Saliva Predict COVID-19 Severity

The paper examines the relationship between salivary microbiome and host parameters in COVID-19 patients, finding that microbiome diversity and salivary cytokines predict disease severity.

An evolutionary epigenetic clock in plants

This paper introduces an epigenetic clock based on stochastic DNA methylation changes in plants, enabling high-resolution temporal analysis of phylogenetic relationships.

How PTEN mutations degrade function at the membrane and life expectancy of carriers of mutations in the human brain

This study investigates how PTEN mutations affect conformational dynamics and clinical outcomes, revealing differences in catalytic activity and life expectancy between neurodevelopmental disorder and cancer-related mutations.

Optical Metabolic Imaging Uncovers Sex- and Diet-dependent Lipid Changes in Aging Drosophila Brain

This study uses optical metabolic imaging to show diet and sex influence lipid metabolism in aging Drosophila brains, revealing IIS pathway involvement.

Multi-Molecular Hyperspectral PRM-SRS Imaging

The paper introduces PRM-SRS imaging to visualize and identify multiple lipid species in cells and tissues with high chemical specificity and subcellular resolution.

Super-resolution stimulated Raman Scattering microscopy with A-PoD

The paper introduces A-PoD, a deconvolution algorithm for super-resolution SRS imaging, achieving 52 nm resolution and enabling nanoscopic analysis of biomolecules and metabolic dynamics.

Persistent Immune and Clotting Dysfunction Detected in Saliva and Blood Plasma after COVID-19

The paper identifies persistent immune and clotting dysfunction in saliva and plasma of COVID-19 patients 4-6 weeks post-symptom resolution, highlighting saliva as a viable alternative to plasma for monitoring immune and inflammatory sequelae.

A merger between compatible but divergent genomes supports allopolyploidization in the Brassicaceae family

This study investigates how genome divergence and compatibility contribute to the stabilization of hybrid genomes in an allopolyploid plant species.

Immunisation of ferrets and mice with recombinant SARS-CoV-2 spike protein formulated with Advax-SM adjuvant protects against COVID-19 infection

This study develops a recombinant SARS-CoV-2 spike protein vaccine, Covax-19, formulated with Advax-SM adjuvant, showing protection against COVID-19 in mice and ferrets.

Functional characterization of SARS-CoV-2 vaccine elicited antibodies in immunologically naive and pre-immune humans

This study compares antibody responses to SARS-CoV-2 vaccination in pre-immune and immunologically naive individuals, finding higher neutralizing antibody levels in pre-immune participants.

The mechanism of activation of monomeric B-Raf V600E

This study uses molecular dynamics to analyze wild-type and V600E B-Raf, revealing how the mutation affects activation pathways and stabilizes the active state through specific interactions.

Hemagglutination Inhibition (HAI) Antibody Landscapes after Vaccination with diverse H7 hemagglutinin (HA) proteins

This study evaluates antigenic differences among H7 influenza HA proteins by vaccinating mice with VLPs and identifies key mutations affecting vaccine efficacy.

Prime editing enables precise genome editing in mouse liver and retina

This study demonstrates that prime editing can correct disease-causing mutations in adult mouse liver and retina, with minimal off-target effects.

Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions and monocytes for optimal therapeutic protection

This study shows that neutralizing antibodies against SARS-CoV-2 need intact Fc functions and monocytes for optimal therapeutic protection in animal models.

Soluble Spike DNA vaccine provides long-term protective immunity against SAR-CoV-2 in mice and nonhuman primates

This study develops a DNA vaccine against SARS-CoV-2, GX-19, showing protective immunity in mice and nonhuman primates with durable antibody and T cell responses.

The structural basis of the oncogenic mutant K-Ras4B homodimers

This study uses molecular dynamics simulations to analyze the stability and conformational changes of K-Ras4BG12D homodimers and their mutants, focusing on two dimerization interfaces.

Three-dimensional beating dynamics of Chlamydomonas flagella

This study uses a multi-plane phase-contrast microscope to observe three-dimensional torsional dynamics of Chlamydomonas flagella and proposes a mechanism involving dynein motors and intrinsic twist.

Respiratory and gut microbiota in commercial turkey flocks with disparate weight gain trajectories display differential compositional dynamics

This study compares respiratory and gut microbiota in two turkey flocks with different weight gain trajectories, finding that microbial composition changes over time and correlates with weight gain differences.

Cost implications of a nationwide survey of schistosomiasis and other intestinal helminthiases in Sudan

This study reports the financial and economic costs of a nationwide schistosomiasis and intestinal helminthiases survey in Sudan, identifying personnel and transportation as key cost drivers.

Wavelength-encoded laser particles for massively-multiplexed cell tagging

This paper introduces laser particles for multiplexed cell tagging and imaging, demonstrating their stability, biocompatibility, and ability to track individual cells in 3D tumor models.

Calotropis gigantea extract induces apoptosis through extrinsic/intrinsic pathways and upregulation of reactive oxygen species in non-small-cell lung cancer cells

This study shows that Calotropis gigantea extract induces apoptosis in NSCLC cells via extrinsic and intrinsic pathways and ROS generation.

MMOD-induced structural changes of hydroxylase in soluble methane monooxygenase

The paper reports the crystal structure of the MMOH-MMOD complex, revealing how MMOD inhibits MMOH catalytic activity by competing with MMOB and altering the di-iron centre geometry.