Author

R. Nussinov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:mechanistic / dynamical model· 3 Research Focus:protein folding & dynamics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

H. Jang· 4 shared A. Gursoy· 1 shared A. Kumawat· 1 shared J. Chen· 1 shared K. Kosoglu· 1 shared K. Sinha· 1 shared L. M. Iakoucheva· 1 shared M. E. Omur· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersBiophysics

H. Jang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Molecular Mechanism of Regulation of RhoA GTPase by Phosphorylation of RhoGDI

K. Sinha, A. Kumawat, H. Jang, R. Nussinov, S. Chakrabarty

This study investigates how phosphorylation of RhoGDI regulates RhoA GTPase activation through molecular dynamics simulations and binding free energy calculations.

bioRxiv · May 10, 2023Biophysics

How PTEN mutations degrade function at the membrane and life expectancy of carriers of mutations in the human brain

H. JANG, J. Chen, L. M. Iakoucheva, R. Nussinov

This study investigates how PTEN mutations affect conformational dynamics and clinical outcomes, revealing differences in catalytic activity and life expectancy between neurodevelopmental disorder and cancer-related mutations.

bioRxiv · Jan 26, 2023 · PreprintBiophysics

The mechanism of activation of monomeric B-Raf V600E

R. C. Maloney, M. Zhang, H. JANG, R. Nussinov

This study uses molecular dynamics to analyze wild-type and V600E B-Raf, revealing how the mutation affects activation pathways and stabilizes the active state through specific interactions.

bioRxiv · Apr 6, 2021Cancer Biology

The structural basis of the oncogenic mutant K-Ras4B homodimers

K. Kosoglu, M. E. Omur, H. Jang, R. Nussinov, O. Keskin, A. Gursoy

This study uses molecular dynamics simulations to analyze the stability and conformational changes of K-Ras4BG12D homodimers and their mutants, focusing on two dimerization interfaces.

bioRxiv · Sep 7, 2020 · PreprintBiophysics