Author

L. M. Pietrek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:protein folding & dynamics· 3 Approach:statistical model· 3 Approach:deep learning· 2 Assay:protein structure· 2 Approach:mechanistic / dynamical model· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

G. Hummer· 4 shared L. S. Stelzl· 4 shared A. Holla· 1 shared B. Schuler· 1 shared D. Dormann· 1 shared D. Edbauer· 1 shared E. L. Sternburg· 1 shared F. Simonetti· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersBiophysics

G. Hummer

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Author profile →

4 papers

Recent·Most cited

Hierarchical assembly of single-stranded RNA

L. M. Pietrek, L. S. Stelzl, G. Hummer

This study introduces a method to assemble ssRNA structures using hierarchical chain growth, showing agreement with experimental data and improving accuracy with Bayesian refinement.

bioRxiv · Aug 1, 2023Biophysics

Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation

L. A. Gruijs da Silva, F. Simonetti, S. Hutten, H. Riemenschneider, E. L. Sternburg, L. M. Pietrek, J. Gebel, V. Doetsch, D. Edbauer, G. Hummer, L. S. Stelzl, D. Dormann

This study shows that hyperphosphorylation of TDP-43 reduces its phase separation and aggregation, suggesting it may act as a protective mechanism against neurodegeneration.

The EMBO Journal · Feb 3, 2022Peer-reviewedBiochemistry

Global Structure of the Intrinsically Disordered Protein Tau Emerges from its Local Structure

L. S. Stelzl, L. M. Pietrek, A. Holla, J. S. Oroz, M. Sikora, J. Köfinger, B. Schuler, M. Zweckstetter, G. Hummer

This study uses a computational method to model the structural ensemble of tau K18, showing how local structure influences global conformational states and disease-related aggregation.

bioRxiv · Nov 23, 2021Biophysics

Hierarchical Ensembles of Intrinsically Disordered Proteins at Atomic Resolution in Molecular Dynamics Simulations

L. M. Pietrek, L. S. Stelzl, G. Hummer

This study uses molecular dynamics simulations to generate diverse structural ensembles of intrinsically disordered proteins at atomic resolution, capturing both local and global structures.

bioRxiv · Aug 9, 2019Biophysics