M. Zweckstetter

p23-FKBP51 chaperone complex regulates tau aggregation

This study identifies the p23-FKBP51 chaperone complex as an Hsp90-independent regulator of tau aggregation, showing it forms a trimeric complex that inhibits tau fibril formation.

GSK3β phosphorylation catalyzes the aggregation of Tau into Alzheimer's disease-like amyloid strain

This study shows GSK3β phosphorylation drives tau aggregation into Alzheimer's-like amyloid strains through enhanced phase separation.

Contributions of the N-terminal intrinsically disordered region of the SARS-CoV-2 nucleocapsid protein to RNA-induced phase separation

This study investigates how the N-terminal intrinsically disordered region of SARS-CoV-2 nucleocapsid protein influences RNA-induced phase separation and its implications for viral replication.

Hsp multichaperone complex buffers pathologically modified Tau

This study identifies the Hsp70/Hsp90 multichaperone complex as a critical regulator of Tau by stabilizing it and preventing aggregation, with p23 enhancing complex formation and CHIP facilitating degradation.

Global Structure of the Intrinsically Disordered Protein Tau Emerges from its Local Structure

This study uses a computational method to model the structural ensemble of tau K18, showing how local structure influences global conformational states and disease-related aggregation.

The Pathogenic R5L Mutation Disrupts Formation of Tau Complexes on the Microtubule by Altering Local N-Terminal Structure

This paper investigates the R5L mutation in Tau, showing it does not reduce microtubule-binding affinity but alters N-terminal structure, impairing Tau complex formation on microtubules.

Molecular basis of small-molecule binding to α-synuclein

The paper uses molecular dynamics simulations to study small-molecule binding to α-synuclein, revealing dynamic interactions that align with experimental data.

Doxycycline interferes with tau amyloid aggregation abolishing its associated neuronal toxicity

This study shows doxycycline reduces tau protein aggregation and toxicity in cell-free and cell culture systems, suggesting its potential repurposing for tauopathies.

Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates

This study shows that SARS-CoV-2 nucleocapsid protein forms RNA-rich condensates via phase separation, which recruit the viral RNA polymerase to enhance transcription.

Cooperativity of membrane-protein and protein-protein interactions control membrane remodeling by epsin 1 and regulate clathrin-mediated endocytosis

This study shows that phosphatidylserine regulates epsin1's membrane remodeling activity, which is essential for clathrin-mediated endocytosis.

Dynamic Aha1 Co-Chaperone Binding to Human Hsp90

This study determines the solution structure of the Hsp90/Aha1 complex using NMR, revealing structural changes induced by Aha1 and a two-step binding mechanism.