Green self-immolative polymer: molecular antenna to collect and propagate the signal for zymogen activation
M. C. Montasell, P. Monge, S. Carmali, L. Mesquita, D. Andersen, K. Lovschall, A. Sogaard, M. Kristensen, J. Pütz, A. N. Zelikin
The paper introduces chemical zymogens activated by protein-protein interactions, demonstrating that a polymer-based fuse can relay activation signals to enzyme active sites.
bioRxiv · Jul 25, 2021 · PreprintBiochemistry