Discovery of indole-modified aptamers for highly specific recognition of protein glycoforms
A. Yoshikawa, A. E. Rangel, T. Feagin, E. Chun, L. Wan, A. Li, L. Moekl, M. Eisenstein, S. Pitteri, H. T. Soh
This paper develops indole-modified aptamers using FACS to specifically recognize protein glycoforms, achieving discrimination between structurally similar molecules differing only in glycan modifications.
bioRxiv · Mar 13, 2021Bioengineering