Effect of expression of human glucosylceramidase 2 isoforms on lipid profiles in COS-7 cells
P. Jatooratthawichot, C. Talabnin, L. Ngiwsara, Y. H. Rustam, J. Svasti, G. E. Reid, J. R. Ketudat Cairns
This study expresses nine human GBA2 isoforms in COS-7 cells and finds that only isoform 1 shows significant activity in hydrolyzing GlcCer, affecting sphingolipid levels.
bioRxiv · Jul 6, 2020Biochemistry