G. E. Reid

Multi-omics characterization of highly enriched human plasma extracellular vesicles.

This study isolates and characterizes small extracellular vesicles from human plasma using multi-omics approaches, revealing novel protein and lipid profiles with potential biomarker value.

Lipid remodeling by hypoxia aggravates migratory potential in pancreatic cancer while maintaining membrane homeostasis

This study shows hypoxia-induced lipid remodeling in pancreatic cancer cells increases migratory potential without altering membrane biophysical properties.

Protein painting reveals pervasive remodeling of conserved proteostasis machinery in response to pharmacological stimuli.

The paper uses protein painting to show how pharmacological stimuli remodel conserved proteostasis machinery across the proteome in whole cells.

Hidden information on protein function in censuses of proteome foldedness

The paper shows proteome folding stability censuses are unreliable due to hidden information on conformation and ligand binding.

Effect of expression of human glucosylceramidase 2 isoforms on lipid profiles in COS-7 cells

This study expresses nine human GBA2 isoforms in COS-7 cells and finds that only isoform 1 shows significant activity in hydrolyzing GlcCer, affecting sphingolipid levels.

A novel function of sphingosine kinase 2 in the metabolism of sphinga-4,14-diene lipids.

This study identifies a novel role for sphingosine kinase 2 in the metabolism of sphinga-4,14-diene lipids, showing that its absence leads to their accumulation in the brain due to slower catabolism.

Arginine valency in C9ORF72 dipolypeptides mediates promiscuous proteome binding that stalls ribosomes, disable actin cytoskeleton assembly and impairs arginine methylation of endogenous proteins

This study shows that arginine valency in C9ORF72 DPRs causes promiscuous proteome binding, ribosome stalling, actin cytoskeleton disruption, and arginine hypomethylation.

Widespread remodelling of proteome solubility in response to different protein homeostasis stresses

The paper measures proteome solubility changes in Neuro2a cells under various protein homeostasis stresses and finds widespread remodelling with specific patterns of solubility shifts.