Role of molecular polymorphism in defining tau filament structures in neurodegenerative diseases
X. Xiang, T. Arakhamia, Y. Carlomagno, S. Dhingra, M. Thierry, M. DeTure, C. N. Cook, D. W. Dickson, L. Petrucelli, A. Fitzpatrick
This study determines the structure of twisted tau filaments in progressive supranuclear palsy and compares them to tau folds in corticobasal degeneration, identifying molecular polymorphism as a factor in filament morphology.
bioRxiv · May 24, 2021 · PreprintBiophysics