X. Xiang

A conserved lysine/arginine-rich motif in potyviral 6K1 protein is key in engaging autophagy-mediated self-degradation for completing pepper veinal mottle virus infection

This study identifies a conserved lysine/arginine-rich motif in potyviral 6K1 protein that mediates autophagy-mediated self-degradation, essential for viral infection.

VezA/vezatin facilitates proper assembly of the dynactin complex in vivo

This study identifies VezA/vezatin as a factor essential for dynactin complex assembly in Aspergillus nidulans, highlighting its role in connecting Arp1 mini-filament and pointed-end sub-complex.

The Transcription Factor OsNAC5 Mediates Cadmium Stress Response and Accumulation in Rice

This study identifies OsNAC5 as a transcription factor that regulates Cd uptake in rice by activating OsNRAMP1, reducing Cd accumulation in grains.

Ultrastructural, metabolic and genetic determinants of the acquisition of macrolide resistance by Streptococcus pneumoniae

This study identifies molecular and metabolic factors that influence the acquisition of macrolide resistance in Streptococcus pneumoniae through chromosomal and ICE integration.

Tip60-mediated Rheb acetylation links palmitic acid with mTORC1 activation and insulin resistance

This study shows that palmitic acid induces mTORC1 activation via Tip60-mediated Rheb acetylation, leading to insulin resistance, while unsaturated fatty acids do not.

The Multifaceted Effects of Short-Term Acute Hypoxia Stress: Insights into the tolerance mechanism of Propsilocerus akamusi (Diptera: Chironomidae)

This study investigates how P. akamusi tolerates acute hypoxia through multi-omics analysis, revealing metabolic and enzymatic adaptations that support its survival in eutrophic lakes.

Aspergillus SUMOylation mutants have normal dynein function but exhibit chromatin bridges

This study identifies SUMOylation defects in Aspergillus nidulans leading to chromatin bridges during mitosis without affecting dynein function.

Kinesin-1 autoinhibition facilitates the initiation of dynein cargo transport

This study identifies kinesin-1 autoinhibition as a novel regulatory factor that facilitates dynein cargo initiation, distinct from LIS1-promoted dynein switching.

Processing Stage Flexibility of the SNARC effect: Task Relevance or Magnitude Relevance?

This study investigates the SNARC effect's processing stage flexibility by comparing magnitude and parity Stroop effects across tasks, finding magnitude-relevant interference information primarily influences the SNARC effect.

Role of molecular polymorphism in defining tau filament structures in neurodegenerative diseases

This study determines the structure of twisted tau filaments in progressive supranuclear palsy and compares them to tau folds in corticobasal degeneration, identifying molecular polymorphism as a factor in filament morphology.

Dynein activation in vivo is regulated by the nucleotide states of its AAA3 domain

This study shows that dynein activation in Aspergillus nidulans is regulated by the nucleotide states of its AAA3 domain, with ATP hydrolysis and binding affecting LIS1 interaction and cargo binding.

An updated assembly strategy helps parsing the cryptic mitochondrial genome evolution in plants

The paper develops a new assembly strategy to improve mitogenome reconstruction in plants, revealing mosaic structures and horizontal transfer contributions to mitochondrial evolution.

SARS-CoV-2 Quasispecies provides insight into its genetic dynamics during infection

The paper analyzes SARS-CoV-2 quasispecies structure using SMRT sequencing, revealing a One-King model with dominant and minor haplotypes and their evolutionary dynamics.

Glucose starvation to rapid death of Nrf1, but not Nrf2, deficient hepatoma cells from its fatal defects in the redox metabolism reprogramming

This study shows Nrf1-deficient hepatoma cells die rapidly under glucose starvation due to redox metabolism defects, unlike Nrf2-deficient cells.

Existence and functions of hypothalamic kisspeptin neuropeptide signaling system in a non-chordate deuterostome species

This study identifies and characterizes the kisspeptin system in the sea cucumber Apostichopus japonicus, revealing its existence and function in a non-chordate species.

Insights into LIS1 function in cargo-adapter-mediated dynein activation in vivo

This study identifies LIS1's role in promoting dynein activation by switching it from an auto-inhibited to active state through cargo-adapter interactions in Aspergillus nidulans.