Anoikis resistance and metastasis of ovarian cancer can be overcome by CDK8/19 Mediator kinase inhibition.
M. Monavarian, R. Rajkarnikar, E. F. Page, A. Kumari, L. Q. Macias, F. Massicano, N. Y. Lee, S. Sahoo, N. Hempel, M. K. Jolly, L. Ianov, E. Worthey, A. Singh, I. Roninson, E. V. Broude, , K. Mythreye
This study shows CDK8/19 inhibition can reverse anoikis resistance and metastasis in ovarian cancer by altering transcriptional programs.
bioRxiv · Dec 4, 2023Cancer Biology