Author

K. Mythreye

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 7 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:experimental assay· 6 Assay:bulk RNA-seq· 5 Research Focus:cancer & tumor microenvironment· 4 Research Focus:cell signaling & trafficking· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Assay:proteomics· 2

Frequent Co-Authors

N. Hempel· 7 shared N. Y. Lee· 4 shared R. Phaeton· 4 shared A. S. Choi· 3 shared M. Monavarian· 3 shared R. C. Arend· 3 shared A. K. Shelton· 2 shared A. Kumari· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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7 shared papersCancer Biology

N. Hempel

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

GPX3 supports ovarian cancer tumor progression in vivo and promotes expression of GDF15

C. Chang, Y.-Y. Cheng, S. Kamlapurkar, S. R. White, P. W. Tang, A. T. Elhaw, Z. Javed, K. M. Aird, K. Mythreye, R. Phaeton, N. Hempel

This study shows GPX3 is necessary for ovarian cancer growth in vivo and promotes GDF15 expression, linking it to immune checkpoint inhibitor response.

bioRxiv · Jan 24, 2024Cancer Biology

Anoikis resistance and metastasis of ovarian cancer can be overcome by CDK8/19 Mediator kinase inhibition.

M. Monavarian, R. Rajkarnikar, E. F. Page, A. Kumari, L. Q. Macias, F. Massicano, N. Y. Lee, S. Sahoo, N. Hempel, M. K. Jolly, L. Ianov, E. Worthey, A. Singh, I. Roninson, E. V. Broude, , K. Mythreye

This study shows CDK8/19 inhibition can reverse anoikis resistance and metastasis in ovarian cancer by altering transcriptional programs.

bioRxiv · Dec 4, 2023Cancer Biology

Heparan sulfate modifications of betaglycan promote TIMP3-dependent ectodomain shedding to fine-tune TGF-β signaling.

A. S. Choi, L. M. Jenkins-Lane, W. Barton, A. Kumari, C. Lancaster, C. Raulerson, H. Ji, D. Altomare, M. D. Starr, R. Whitaker, R. Phaeton, R. C. Arend, M. Shtutman, A. B. Nixon, N. Hempel, , K. Mythreye

This study identifies heparan sulfate modifications as critical for betaglycan ectodomain shedding, which regulates TGF-β signaling and has clinical implications in ovarian cancer.

bioRxiv · Aug 29, 2023 · PreprintBiochemistry

PVT1, a YAP1 dependent stress responsive lncRNA drives ovarian cancer metastasis and chemoresistance

K. Tabury, M. Monavarian, E. Listik, A. K. Shelton, A. S. Choi, R. Quintens, R. C. Arend, N. Hempel, C. R. Miller, B. Györrfy, K. Mythreye

This study identifies PVT1, a YAP1-dependent stress-responsive lncRNA that promotes ovarian cancer metastasis and chemoresistance, suggesting it as a therapeutic target.

bioRxiv · Jan 11, 2022 · PreprintCancer Biology

Reciprocal epigenetic Sox2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer

Z. SHONIBARE, M. Monavarian, K. O'Connell, D. Altomare, A. K. Shelton, S. Mehta, R. Jaskula-Sztul, R. Phaeton, M. D. Starr, R. Whitaker, A. Berchuck, A. Nixon, R. C. Arend, N. Y. Lee, C. R. Miller, , K. Mythreye

This study identifies Sox2 as a key node regulated by opposing TGF-β superfamily signals, impacting anoikis resistance and metastasis in ovarian cancer.

bioRxiv · Jan 11, 2022Cancer Biology

HuR-dependent SOD2 protein synthesis is an early adaptation to anchorage independence

Y. S. Kim, J. E. Welles, P. W. Tang, Z. Javed, A. T. Elhaw, K. Mythreye, S. R. Kimball, N. Hempel

This study shows that HuR-dependent SOD2 protein synthesis is an early adaptation to anchorage independence in ovarian cancer cells.

bioRxiv · Feb 19, 2021Cancer Biology

A meta-analysis of the inhibin network reveals prognostic value in multiple solid tumors

E. Listik, B. Horst, A. S. Choi, N. Lee, B. Gyorffy, K. Mythreye

This study performs a meta-analysis of the inhibin network to assess its prognostic value in multiple solid tumors, identifying key dependencies and therapeutic implications.

bioRxiv · Jun 25, 2020Cancer Biology

Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells.

Y. S. Kim, P. Gupta-Vallur, V. M. Jones, B. L. Worley, S. Shimko, D.-H. Shin, L. C. Crawford, C.-W. Chen, K. M. Aird, T. Abraham, T. G. Shepherd, J. I. Warrick, N. Y. Lee, R. Phaeton, K. Mythreye, N. Hempel

This study shows that SIRT3 activation is required for ovarian cancer cell survival and metastasis by regulating mitochondrial antioxidant defenses and metabolic changes during detachment.

bioRxiv · Jun 13, 2019Cancer Biology