The complex inhibitory mechanism of glycomimetics with human heparanase
C. Whitefield, Y. Vo, B. D. Schwartz, C. Hepburn, F. H. Ahmed, H. Onagi, M. G. Banwell, K. Nelms, L. R. Malins, C. J. Jackson
This study investigates the complex inhibitory mechanism of PPS on HPSE, revealing multiple overlapping binding events influenced by oligosaccharide length and protein structure changes.
bioRxiv · Jan 5, 2023 · PreprintBiochemistry