Large-scale curvature sensing by epithelial monolayers depends on active cell mechanics and nuclear mechanoadaptation
M. Luciano, S.-L. Xue, W. H. De Vos, L. Redondo Morata, M. Surin, F. Lafont, E. Hannezo, S. Gabriele
This study shows that epithelial monolayers sense substrate curvature through changes in cell and nuclear shape, thickness, and YAP distribution, mediated by active cell mechanics and nuclear mechanoadaptation.
Nature Physics · Dec 1, 2021Peer-reviewedBiophysics