M. Luciano

A minimal physical model for curvotaxis driven by curved protein complexes at the cell's leading edge

This paper develops a minimal physical model to explain curvotaxis by simulating curved protein complexes at the cell's leading edge and shows it matches experimental observations on curved substrates.

Mechanoresponse of epithelial monolayers to in-plane and out-of-plane curvatures imposed by 3D microwells

This study investigates how in-plane and out-of-plane curvatures affect epithelial tissue mechanics using 3D microwells, showing curvature-induced changes in cell orientation, nuclear morphology, and cellular trafficking.

Geometry-driven migration efficiency of autonomous epithelial cell clusters

This study investigates how the geometry of microstripes affects the migration efficiency of epithelial cell clusters and identifies interaction rules governing their movement in complex environments.

Large-scale curvature sensing by epithelial monolayers depends on active cell mechanics and nuclear mechanoadaptation

This study shows that epithelial monolayers sense substrate curvature through changes in cell and nuclear shape, thickness, and YAP distribution, mediated by active cell mechanics and nuclear mechanoadaptation.

The NLRP3/eIF2 axis drives cell cycle progression in acute myeloid leukemia

This study shows that inhibiting the NLRP3 inflammasome reduces AML cell proliferation by promoting eIF2 phosphorylation and cell cycle arrest.

A plant lipocalin is required for retinal-mediated de novo root organogenesis

The paper identifies a plant lipocalin, TIL, that is required for retinal-mediated de novo root organogenesis in Arabidopsis.