HIV-1 co-receptor usage and variable loop contact impacts V3 loop bnAb susceptibility
L. Registre, Y. Moreau, S. Toksoz Ataca, S. Pulukuri, T. J. Henrich, N. Lin, M. Sagar
The paper develops a sequence-based algorithm to predict HIV-1 receptor usage and bnAb susceptibility, showing that CXCR4-using strains are less susceptible to V3 loop bnAbs due to structural interactions.
bioRxiv · Mar 5, 2019Microbiology