Author

L. Riggan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

T. E. O'Sullivan· 2 shared A. P. Arnold· 1 shared C. Huerta· 1 shared E. Perez Reyes· 1 shared F. Ma· 1 shared H. Hrncir· 1 shared J. H. Li· 1 shared M. A. Su· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

T. E. O'Sullivan

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2 papers

Recent·Most cited

Sex differences in NK cells mediated by the X-linked epigenetic regulator UTX

M. I. Cheng, L. Riggan, J. H. Li, R. Y. Tafti, S. Chin, F. Ma, M. Pellegrini, H. Hrncir, A. P. Arnold, T. E. O'Sullivan, M. A. Su

This study identifies UTX as a key X-linked epigenetic regulator causing sex differences in NK cell function, with males showing reduced IFN-γ production despite higher numbers.

bioRxiv · Apr 21, 2022 · PreprintImmunology

NK cells promote cancer immunoediting through tumor-intrinsic loss of interferon-stimulated gene expression

Y. Y. Wong, L. Riggan, C. Huerta, M. Moldenhauer, E. Perez Reyes, T. E. O'Sullivan

This study shows that NK cell-edited tumors lose IFN-γ-inducible gene expression, and high expression of three genes correlates with better patient survival in breast, melanoma, and sarcoma.

bioRxiv · Nov 23, 2020 · PreprintImmunology