Cell BiologybioRxiv
Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis
C. J. Brereton, L. Yao, Y. Zhou…·M. Jones
This study shows that pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis by promoting bone-type cross-linking and increasing tissue stiffness.
DOI 10.7554/elife.69348