Author

L. Seefeldt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

B. Kacar· 2 shared D. Harris· 2 shared A. Garcia· 1 shared A. K. Garcia· 1 shared A. P. Barros· 1 shared A. Rivier· 1 shared B. Carruthers· 1 shared H. Feinsilber· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersEvolutionary Biology

B. Kacar

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2 papers

Recent·Most cited

The Origins of ATP Dependence in Biological Nitrogen Fixation

D. Harris, H. Rucker, A. Garcia, Z.-Y. Yang, S. Chang, H. Feinsilber, B. Kacar, L. Seefeldt

This study experimentally reconstructs an ancestral nitrogenase enzyme and shows it strictly requires ATP hydrolysis for N2 reduction, decoupling cofactor selection from environmental availability.

bioRxiv · Feb 22, 2024 · PreprintEvolutionary Biology

Nitrogenase resurrection and the evolution of a singular enzymatic mechanism

A. K. Garcia, D. Harris, A. Rivier, B. Carruthers, A. P. Barros, L. Seefeldt, B. Kacar

This study resurrects ancient nitrogenase enzymes and shows their in vivo functionality and reversible dinitrogen reduction mechanism, suggesting evolutionary constraints in catalyzing this reaction.

eLife · Feb 17, 2023Peer-reviewedEvolutionary Biology