Loss of FAM111B protease mutated in hereditary fibrosing poikiloderma syndrome negatively regulates telomere length
M. Kliszczak, D. Moralli, J. Jankowska, P. Bryjka, L. Subha, T. Goncalves, S. Hester, R. Fischer, D. Clynes, C. M. Green
This study identifies FAM111B as a regulator of telomere length through interactions with the nuclear pore complex, independent of telomerase, and links its dysfunction to genomic instability in HFP patients.
bioRxiv · Jan 22, 2023 · PreprintCell Biology